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10.1542/peds.2012-1094 25

171 In myeloid cells, Sirt1 downregulates the NFB pathway, decreasing inflammation and promoting metabolic reprogramming through PGC1/AMPK and HIF1 stabilization

The convergence of phenological advancement and altered beach thermal regimes thus creates compounding physiological risks that cannot be fully mitigated through behavioral adjustment alone, underscoring that reptile phenological responses involve complex demographic trade-offs that deserve substantially greater research attention