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Biomark Insights 15:1177271920954828 Cibrian D, de la Fuente H, Snchez-Madrid F (2020) Metabolic pathways that control skin homeostasis and inflammation

Viewing these processes as components of a coordinated intracellular network may improve understanding of how local organelle-level damage is translated into whole-cell dysfunction and, ultimately, systemic disease manifestations

Initial symptoms often include fever, headache, fatigue, and a characteristic skin rash called erythema migrans (a bullseye rash only present in less than 10% of cases)

In addition, cancer stem cells and cancer cells with plasticity may also generate neuro-like cells within tumors