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Determining the ability of the test compound to modulate the activity of NOVX can be accomplished, for example, by determining the ability of the NOVX protein to bind to a NOVX target molecule by one of the methods described above for determining direct binding

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(49) discovered that Oscillibacter species can metabolize cholesterol through dehydrogenation and glycosylation reactions, while Bacteroides thetaiotaomicron correlates positively with plasma cholesterol and cholesterol sulfate levels