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To confirm that haem-assisted dimerization of PGRMC1 occurs in solution, we analysed the structure of apo- and haem-bound PGMRC1 by two-dimensional nuclear magnetic resonance (NMR) using heteronuclear single-quantum coherence and transverse relaxation-optimized spectroscopy (Supplementary Figs 6b and 7)

Upon restoration of the blood supply to the transplanted ovarian tissue, a substantial production of reactive oxygen species occurs, leading to vascular endothelial dysfunction, increased microvascular permeability, tissue edema, and an intensified inflammatory response

However, we also reported a possible off-target effect of daratumumab which result in depletion of other CD38 expressing regulatory cells including Treg, Breg, MDSC etc

This suggests that BDNF may provide potential benefits for AD treatment through its positive modulation of impaired synaptic plasticity and cognitive memory