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There were ads that said things like Two out of three physicians prefer Camels. (Actually it was More doctors smoke Camels than any other cigarette.) It was not until the 80s, when the Congress called the seven CEOs of the major tobacco companies to testify about smoking and health, that the government got serious about the problem

The researchers also conducted a sophisticated bioinformatics analysis to identify the molecular processes, biological pathways and diseases linked to the gene expression changes they observed

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Its a complex process , but its not magic