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Hojyo S, Uchida M, Tanaka K, Hasebe R, Tanaka Y, Murakami M, et al

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134 Under chronic inflammatory conditions, lipopolysaccharide induces PDK4 expression by activating the JNK pathway instead of p38 or ERK, thereby inhibiting the activity of the pyruvate dehydrogenase complex and promoting lactate production

The collaborative action of these compounds presents a holistic strategy that holds promise for potentially addressing conditions associated with inflammation, including arthritis, inflammatory bowel disease, and tendonitis