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Mapping of the receptors showed that CGRP receptors are predominantly situated in the bronchial vessels, in the epithelium of the human airways, and in the smooth muscles on which it has effects on tone by acting indirectly through the release of other constrictors, such as endothelin

(May 2016)

For instance, the nitric oxide reductase NorB and the cytochrome c (CycP) detoxified NO produced by macrophages (Stevanin et al., 2005), while PorB-TLR2 interaction enhances anti-inflammatory IL-10 production (Samarasinghe et al., 2006) and modulates Nf-B signaling (Oliveira-Nascimento et al., 2012), reprogramming dendritic cells toward a Th2 response (Mukherjee et al., 2016)

doi: 10.1002/bies.20002 80 LiXWangJ