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Drug tolerance is a pharmacological concept describing the patient's reduced affinity to a drug after sustained exposure to that drug

J Biol Chem 292:1680416809 Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ (2000) Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes

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