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Six trials totaling roughly 900 participants are summarized in Stier et al

In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected

Negative effects are rare but may include: Mild discomfort at the injection site, temporary diarrhea, allergic reactions, or rash

Reviews of the rodent work note that the mechanism doesnt involve the hormonal suppression or receptor desensitization that would predict tolerance or rebound, and that adipose SAM levels tend to normalize rather than crash under inhibition