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Dermal tissue biopsies taken 24 hours post-injection show residual peptide concentrations at 512% of peak levels, sufficient to maintain gene expression changes initiated during the first-pass exposure

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Research demonstrates that TB-500 forms functional complexes with PINCH-1 and integrin-linked kinase (ILK) that can inhibit TNF--induced NF-B activation through blocking RelA/p65 translocation, providing rapid suppression of inflammatory transcriptional programs