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doi: 10.3390/pharmaceutics15010275

Single particle cryo-EM data were collected at the University of Texas Southwestern Medical Center (UTSW) Cryo-Electron Microscopy Facility that is funded by a Cancer Prevention and Research Institute of Texas (CPRIT) Core Facility Support Award (RP170644)

The inhibition of the TKTL1 activity has been shown to repress the proliferation of hepatoma cells (Zhang et al., 2007)

In the CNS many of the pathological effects of kynurenine pathway activity may result from a balance between the concentrations of quinolinic acid, an agonist at glutamate receptors sensitive to N-methyl-D-aspartate (NMDA) ( In addition, over-activation of NMDA receptors is accompanied by increased microglial proliferation and activation together with cytokine production