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We used NMR spectroscopy to identify the crucial region within the p53 TAD responsible for FOXO4 binding (Figure

The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity

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Body composition data should be interpreted cautiously due to the small subgroup analysis