how does glutathione s-transferase cause drug resistance in cancer cells

how does glutathione s-transferase cause drug resistance in cancer cells Unveiling the Role of Protein Breast Resistance: Insights into the Signaling Pathways and Therapeutic Implications Glutathione S-transferase Theta 2 causes

Name: how does glutathione s-transferase cause drug resistance in cancer cells Unveiling the Role of Protein Breast Resistance: Insights into the Signaling Pathways and Therapeutic Implications Glutathione S-transferase Theta 2 causes
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Glutathione S transferase Theta 2 causes drug resistance by inhibiting arsenic trioxide induced ferroptosis in pancreatic ductal adenocarcinoma ScienceDirect Glutathione transferases: substrates, inihibitors and pro drugs in cancer and neurodegenerative diseases Oncogenesis can glutathione cause breast tenderness Unveiling the Role of S transferase Protein in Cancer Drug Resistance: Insights into the Signaling Pathways and Therapeutic Implications Comprehensive single cell metabolic profiling identifies Overexpression of Glutathione S Transferases in Human Diseases: Drug Targets and Therapeutic Implications

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demonstrated in patients with advanced colorectal cancer treated by either anti-EGFR inhibition or without, the expression of autophagy proteins Beclin-1 and LC3 were not only associated with advanced colorectal cancer, but those with higher expression of these proteins experienced worse objective response rates, and shorter progression free survival

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Ferroptosis, characterized by GPX4 inhibition and iron-dependent lipid peroxidation, occurs in iron-rich cells such as glioblastomas and neurons, and is often triggered by decreased SLC7A11 expression or cystine depletion