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Papadaki, M., Koutsopoulos, A., Tsoulfas, P., Lagoudaki, E., Aggouraki, D., Monastirioti, A

Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome

These findings highlight the importance of brain endothelial CYP1B1 in maintaining BBB integrity, as its deficiency exacerbated Mn-induced BBB disruption, increased brain Mn accumulation, and worsened dopaminergic neurodegeneration, underscoring the critical role of the endothelium in mediating Mn neurotoxicity