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Houtkooper, R

E.OlafimihanA

Interestingly, we observed an increase in oxidative glucose metabolism on a protein abundance level in tumor tissue, which is in line with previous proteomics studies 16,17

Results obtained from randomized clinical trials, however, were inconsistent and in some circumstances have indicated that antioxidants increase cancer risk ( N -acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression ( From these data we can reasoned that by selectively targeting GSH content of cancer cells we can induce apoptosis either directly or by combining therapies with redox antineoplastic agents