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Interestingly, efavirenz also increased levels of CHOP, leading to the expression of apoptotic genes as opposed to the expression of genes mitigating the accumulation of unfolded proteins

The mechanism appeared in part to be due to modulation f the intestinal microbiota by increasing the abundance of Bacillus sp

Tocotrienols are characterized by a chromanol ring attached to an unsaturated isoprenoid side chain, while tocopherols contain a chromanol ring attached to a saturated alkyl side chain