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Burwinkel B, Kreuder J, Schweitzer S, Vorgerd M, Gempel K, Gerbitz KD, Kilimann MW: Carnitine transporter OCTN2 mutations in systemic primary carnitine deficiency: a novel Arg169Gln mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality

Transcriptomic analysis demonstrated anti-inflammatory and anti-apoptotic effects were through MAPK pathway inhibition, showing inhibited phosphorylation of ERKs, JNKs, and p38 MAPKs with downstream upregulation of BCL2 and downregulation of Bax, CASP-3 and cytochrome (cyt) C [139]

It is intended solely for in vitro testing and laboratory experimentation

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