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In vitro extremely high Zn levels (500 M) induce polymorphonuclear leukocytes (PMN) chemotaxis while very low Zn levels decrease PMN chemotaxis (104)

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Specifically in diabetic patients: Modulating the glucose signaling pathway to enhance insulin sensitivity Modulating postprandial glucose levels to regulate glucose metabolism Regulation of lipid metabolism by controlling postprandial insulin secretion Improving activity of pancreatic islet by enhancing pancreatic beta cell function and inhibiting apoptotic processes involved in beta cell malfunction Reducing free radical overload and improving insulin resistance by lowering oxidative stress Inhibition of inflammatory responses through alleviation of inflammatory mediators By therapeutic application of trehalose may mitigate secondary complications [473]

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