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The control variables included (1) number of years from the first-ever schizophrenia diagnosis date in Medicare claims (see Supplementary Methods) until the starting date of each subperiod, (2) number of inpatient stays or emergency room visits with a diagnosis of schizophrenia in the first or second position on the claim within 3 months before the starting date of a subperiod, and (3) temporal order of exposure (i.e., number of treatments used before this subperiod)

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Community protocols generally cluster between 20 and 100 mcg per day, given as one daily injection because of the long half-life