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It means that excess amounts are typically excreted through urine rather than accumulating to toxic levels , making vitamin B12 supplementation generally safe even at higher doses, though adverse reactions such as hypersensitivity or acneiform rash can occur rarely

5 When ingested, the body must break it down into its active form before it can be used, which may be difficult for people with SNPs (genetic mutations) on B12 metabolic pathways

Increased ROS production promotes viral establishment during acute infections, whereas Nrf2 activation may be beneficial to the virus by increasing the host cells ability to cope with the oxidative stress resulting from viral infection and/or inflammation

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