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Environmental Health Perspectives, 121 (9), 10681074

What vitamin B 12 can't do The internet is full of articles lauding the use of vitamin B 12 to prevent Alzheimer's disease, heart disease, and other chronic conditions or reverse infertility, fatigue, eczema, and a long list of other health problems

However, it is necessary to consider that the introduction of a new amide bond increases the susceptibility to hydrolysis and the topological polar surface area (TPSA), as well as contributing to the increase of hydrogen bond donor (HBD) or hydrogen bond acceptor (HBA) count