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Men with higher starting weights often require longer treatment durations to achieve target weight loss percentages

Previous work has noted that self-report data remain a valid and useful measure in many contexts 31 , but downward biases in self-reported weight are common 32 and may be influenced by factors including health awareness, culture and social norms 33

This confirms that semaglutide works through direct metabolic mechanisms rather than causing weight loss through discomfort, an important distinction for understanding the medications therapeutic value

ARA290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic pain in spontaneous type 2 diabetes