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Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK

Under conditions of cellular stress, injury, or mitochondrial dysfunction, mtDNA can escape into the cytoplasm, where it activates the cGAS (cyclic GMPAMP synthase)STING (stimulator of interferon genes) signaling pathway, or it can be detected extracellularly by Toll-like receptors on immune cells

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A broadly defined group of mechanisms related to competition for resources could affect both presynaptically active as well as inactive synapses and may help to maintain an overall balance of synaptic weights (Frey and Morris, 2001