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Iron in Neurodegeneration - Cause or consequence

The iron and MDA concentrations were determined using an Iron assay kit (Wuhan Elabscience Biotechnology Co., Ltd.) and a trace MDA assay kit (Beyotime Biotechnology), respectively

Treated groups exhibited synaptic clefts with narrow spacing and sharply defined PSDs, along with presynaptic terminals containing clustered SVs adjacent to membranes

From a principal component analysis, we also found that the reactive individuals had significantly higher PC1 scores (antioxidant axis) compared to the proactive, and a trend for stressed fish having higher PC1 scores than control