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Results We describe parenteral administration of OHCbl using a subcutaneous catheter together with a portable infusion pump in a home therapy setting in four pediatric patients with remethylation disorders, two patients with cblC, one patient with cblG, and one patient with cblE deficiency, in whom intramuscular injections were not or no longer feasible

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In addition, lipid nanocapsules can effectively promote APC lymphatic drainage transport and significantly improve the therapeutic effect of tumor vaccines by loading protein or peptide antigens [95]

Arch Med Res 45(3):247250