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If suspicion of a CMCD is high (clonality prediction score 2), the criterion standard for diagnosing SM or MMAS is a bone marrow biopsy, which should ideally be performed in a center with expertise in SM since the burden of abnormal mast cells is typically quite low in those patients [49, 55, 65]

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The B12 procedure typically involves the administration of vitamin B12 through an injection, as this method allows for direct absorption into the bloodstream.The injections are quick and relatively painless, with the practitioner typically targeting the upper arm or thigh