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Approximately 40 APP mutations and co-localization of proteins with A [103] responsible for causing AD have been identified

114,115,116 Whereas the canonical reactions catalysed by CBS and CSE within the trans-sulphuration pathway sequentially convert homocysteine into cysteine, both enzymes catalyse a number of alternative H 2 S-yielding reactions, using as substrates different combinations of these very same sulphur amino acids (reviewed e.g

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10,11 In the most severe forms of COVID-19, in addition to the cytokine storm, an imbalance of oxidative stress has been shown to occur