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Hydroxocobalamin BNF Drug Monograph

This indicates that alterations in intestinal epithelium integrity caused by genetic or environmental factors contributes to the translocation of luminal microbes that can become immunogenic when delocalised from their GI niche (Fine et al

1.1 Development of thyroid autoimmunity Under physiological conditions, central immune tolerance eliminates or inactivates T cells that recognize self-antigens within the thymus