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10.1080/15438600490424389 Exp

One factor in feeling sleepy every night is the buildup of adenosine in the brain

In all our previous murine studies we have used short cycles (1014 days) of very low subcutaneal doses (20 g/kg/day) after carefully assessing its circulating concentrations and using the minimum amount that was sufficient to adequately restore physiological values of the molecule

While a definitive causal relationship has thus far been challenging to define experimentally, substantial work has focused on elucidating the aberrant cellular signaling and phenotypic changes in cardiac cells that take place in the context of ECD (Figure 2)