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Similar results were reported by Gao, et al

10.53388/imd202408005 234 XuC.CaoY.LiuR.LiuL.ZhangW.FangX.et al (2022a)

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

However, the contribution of the existing studies on the gut microbiota to ALI has not been well characterized, which directly leads to the ineffectiveness of strategies targeting the gut microbiota for disease therapy