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However, oral bioavailability is very poor as it is largely broken down by digestive enzymes

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In chemical carcinogenesis models of breast cancer, it has also been demonstrated that synthetic vitamin D analogs increase tumor latency and decrease tumor incidence and recurrence ( Unlike humans, sheep, cattle, horses, pigs, rats, and other mammals, dogs and cats cannot produce vitamin D in their skin by sunlight ( The body responds to calcitriol in a pleiotropic way via the VDR receptor, a transcription factor that is a part of the nuclear hormone receptor family