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DNA damage related crosstalk between the nucleus and mitochondria

Underlying deficiency correction : When severe B12 deficiency is corrected, some patients experience temporary neuropsychiatric symptoms as nerve function recoversa phenomenon sometimes called 'unmasking' of symptoms

For example, in our evaluation of postmortem human brain tissue from individuals with various levels of AD neuropathology, we observed a wide range (0-15%) of senescent cell burden (39)

In order to determine whether the metabolic changes observed in Tbx1 +/ mice were related to the vB12 pathway, we applied NMR-based metabolomic analysis to the four classes (treatments and genotypes), that is, PBS-treated WT and Tbx1 +/ mice and vB12-treated WT and Tbx1 +/ mice