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Moreover, in mouse model of dextran sulfate sodium colitis treated with NPY antisense oligonucleotides, researchers observed decreased TNF- levels and reduced NF-B phosphorylation 15

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2,3 This is of importance because the gut microbiota fulfills many critical roles in essential host functions such as protection against pathogens, immune-system modulation, fermentation of non-digestible dietary fibres, anaerobic metabolism of peptides and proteins, interaction with the hosts circadian clock and biotransformation of xenobiotics