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doi: 10.1111/exd.14042 128 ChangPQuYLiuYCuiSZhuDWangHet al

It is regularly employed as a primary precursor to S-adenosylmethionine (SAMe) in laboratory studies analyzing cellular transmethylation reactions

Notably, the ability of PtpA to regulate GPX4 expression or ferroptosis was lost in cells deficient in PRMT6 or cells treated with a PRMT6 inhibitor, demonstrating that PRMT6 is required for Mtb PtpA-induced ferroptosis