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doi:10.1016/j.amjmed.2012.12.009 [9] Rayman MP

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MiR-21-5p has been reported to be one of the most abundant in exosomes derived from GH-secreting pituitary adenoma and downregulated the Programmed cell death 4/Activator protein 1 (PDCD4/AP-1) pathway by targeting PDCD4 and SMAD Family Member 7 (Smad7) (67) with subsequent distant effects that have been shown in vitro , specifically osteoblast proliferation, differentiation and mineralization (67)

The use of PYO in the degradation of various compounds was previously reported