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They secrete pro-inflammatory mediators and elastase, which induce chondrocyte apoptosis and extracellular matrix (ECM) degradation, thereby promoting the progression of OA ( On one hand, similar to macrophages and other immune cells, neutrophils can secrete interleukin-1 (IL-1), which exacerbates cartilage damage in OA through multiple pathways

2015), rescued the LD biogenesis defects caused by ORP5 depletion (Supp

From time to time, men ask us whether they should opt for hormone replacement therapy or testosterone injections to help fight their aging symptoms

1 Introduction Multiple myeloma (MM), a hematologic malignancy characterized by clonal proliferation of bone marrow plasma cells, manifests clinically through CRAB criteria: hypercalcemia, renal dysfunction, anemia, and osteolytic lesions ( Ferroptosis, an iron-dependent non-apoptotic cell death driven by excessive lipid peroxidation, was first characterized by Dixon et al., in 2012 through studies on erastin and RAS-selective lethal compounds (Zhang et al., 2022