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The estimated mean changes for the plasma SCD-16 index were compatible with reductions in both the Met/Cys -low ( 12.0%, 95% CI 27.8%7.4%) and Met/Cys -medium ( 15.7%, 30.92.84) groups compared to the Met/Cys -high group, but results were inconclusive as indicated by the wide CIs

However, DAMPs-mediated signalling can also generate detrimental effects, particularly when a massive release of pro-inflammatory DAMPs from dying cells causes more cells to die: a situation that strongly contributes to the CD4+ T cell depletion in patients infected with HIV-1 (63, 64), reviewed in (65)