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The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes

As an example, it has been demonstrated that a mutation (S662G) in PER2, which is known to be responsible for the familial advanced sleep phase syndrome, increased resistance to apoptosis and E1A- and RAS-driven oncogenic transformation, as well as affected tumorigenesis in p53 R172H/+ mice, with a cancer-sensitized genetic background 38

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J Gastrointest Liver Dis JGLD 28(1):95105 Barilli A, Rotoli BM, Visigalli R, DallAsta V (2014) Gliadin activates arginase pathway in raw264.7 cells and in human monocytes