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10.1155/2022/4156966 225 ZhaoM.LuT.BiG.HuZ.LiangJ.BianY.et al (2023a)

doi: 10.1109/TCBB.2018.2879504

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These phases are shaped by the paradigm of selecting an initial hit compound from a molecular library, which is then iteratively elaborated into a lead series with improved potency, selectivity, and drug-like properties 15