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6df, GPX4 protein levels were also decreased after treatment with heme, FAC, and erastin in the HNPCs, indicating that all three of these treatments can induce intracellular ROS production and cell death

On the other hand, in the chronic hyperglycemia condition in diabetes, O-GlcNAc transferase reduces the transcription of SERCA2, which results in decreased calcium reuptake and impaired relaxation (55)