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BMC Bioinform 13:S13 Salentin S, Schreiber S, Haupt VJ, Adasme MF, Schroeder M (2015) PLIP: fully automated proteinligand interaction profiler

For example, a melanoma patient presenting with high TMB, robust tumor PD-L1 expression, and a biopsy showing abundant, functionally active CD8 T cells infiltrating tumor nests exemplifies a classic immune-hot profile, which strongly predicts a high potential for a profound initial response to immunotherapies such as ICIs [32, 390]

10.1021/acsami.4c05523 ACS Appl Mater Interfaces

However, most research is conducted on six months trials which suggests that it can be taken for up to six months