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Beyond the outdoors: indoor air quality guidelines and standards challenges, inequalities, and the path forward

10.1016/j.phrs.2023.106837 19 ChourpiliadisC.ZengY.LovikA.WeiD.ValdimarsdottirU.SongH.et al (2024)

Associations between MTHFR C677T and MS vary across populations, some case-control studies identify risk signals, while others do not, supporting a 'substrate-limitation' model where genetic predisposition interacts with B-vitamin status to constrain DNMT activity and stabilize a proinflammatory methylation landscape (7,142,143)