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However, they observed that due to the low methodological quality and the small number of studies included some cautions must be considered with these results

Javanmanesh F, et al

K.TsuboiY.GhettiB.Pickering-BrownS.BabaY.CheshireW

Reduced GCLC promoter activity from this variant produces a lower basal GCLC enzyme pool constraining the rate of -GluCys synthesis from the transcriptional level, upstream of any allosteric or substrate-availability-related regulation