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Inhibition of proteasome activity results in ubiquitination-dependent proteolytic cleavage of Nrf1 by aspartyl protease DNA damage inducible 1 homolog 2 (DDI2), which removes ~100 amino acids from the N-terminal TMD, resulting in Nrf1 activation with the subsequent upregulation of genes required for proteasome biogenesis

Mondal MIH, Chakraborty SC, Rahman MS, Marjuban SMH, Ahmed F, Zhou JL, Zargar M (2024) Adsorbents from rice husk and shrimp shell for effective removal of heavy metals and reactive dyes in water

Additionally, the by-product of H 2 O 2 activates the Erk1/2, which in turn, leads to cell proliferation in human breast cancer via involving estrogenic metabolism

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