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The discontinuation was driven by (Bergam, 2025) (Figure 2): the availability of newer, safer & more accurate alternative testing for MG including electrophysiological & antibody tests, as well as safety concerns (bradycardia & respiratory complications) limited diagnostic reliability (with both false-positive and false-negative results) The decision to remove edrophonium as an available (alternative) diagnostic test has been challenged (Keritam et al, 2026)

Other environmental exposures, which have been related to DNA methylation, such as exposure to tobacco smoke [13-17] and air pollution [18], are out of the focus of the present review, as tobacco smoke and air pollution are mixtures of different types of chemicals rather than individual groups of compounds

New York, NY: American Society for Microbiology Press

Modern clinical research has shown that saffron supplementation (typically 2050mg per day) can improve visual acuity, retinal function, and contrast sensitivity in adults with AMD.58 These effects are attributed to compounds called crocin and crocetin, which may enhance retinal blood flow and protect photoreceptor cells from oxidative stress