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While several interventions have progressed to early- and mid-stage clinical trials, their translational success will likely depend on improved patient stratification based on immune and metabolic profiles, as well as the identification of reliable peripheral biomarkers to monitor target engagement and therapeutic response

To compare the frequency difference between groups, the chi-square test or Fischers exact test was used

doi: 10.1002/pros.2990210307 60 BlackshearPJManzellaJMStumpoDJWenLHuangJKOyenOet al