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Kang et al, 1993)

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2 Tumor-associated macrophages: an in-depth analysis The traditional belief that tumor-associated macrophages (TAMs) solely originate from bone marrow monocytic progenitors has evolved substantially in recent years (23)

Strategies involving pharmacological or genetic inhibition of PGE2 production and signaling, either alone or in combination with PD-1 blockade, have been shown to enhance CD8 + T cell effector function during chronic LCMV infection [71]