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Activation and nuclear translocation of the transcription factor Nuclear Factor Activated T cell (NAFT) has been reported to be an essential mechanism of the hypoxia signaling pathway in human lung fibroblasts [286]

For patients with signs and symptoms of HT, close monitoring of labs (including antibodies that indicate autoimmune involvement) may help doctors detect this disease before serious consequences occur

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These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (52), cells (such as dendritic, B cells, and T cells) (52), and gut microbes or toxins (355) to translocate into the brain and promote inflammation ( Figure 10 )