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In the course of age-related degeneration of the spiral ganglion cells, the autophagy activator rapamycin rescues dying neurons and preserves ganglion cells [73]

101 Moreover, several phase II trials have shown that clioquinol is capable of reducing A aggregation and improving cognitive function, but fail to provide sufficient evidence of a positive benefit in a larger trial

[Research updates: the mechanism of autophagy in inflammatory bowel disease]

Intracellular Antibodies may also be introduced and expressed in one or more cells, tissues or organs of multicellular organisms, for example for prophylactic and/or therapeutic purposes (e.g., as gene therapy) (see at least PCT publication Nos