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Beginners should start lower to reduce irritation

Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

It should also be emphasised that currently we do not recommend the use of simvastatin (particularly in a dose of 80 mg due to adverse reactions), but if the treatment goal has been achieved and the patient tolerates it well, there is no need to change it